Prostate cancer
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AR-V7 Recombinant Rabbit Monoclonal Antibody
AR V7 belongs to the nuclear hormone receptor family. It Contains nuclear receptor DNA-binding domain. Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. This target is a splice variant of Androgen receptor (UniProt P10275) lacking the C-terminal androgen binding site.
Specifications
- Catalog No.
- BX50174
- Clone No.
- BP6152
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Prostate cancer
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Androgen Receptor(AR-V7 specific) aa 600 to the Cterminus.
Reference
1. Chen W et al. J Cell Biochem 120:14055-14064 (2019).
2. Honda M et al. Prostate 79:1043-1052 (2019).
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