Mesothelioma
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BAP-1 Recombinant Rabbit Monoclonal Antibody
"BAP-1 (BRCA-1 Associated Protein-1) is an 80 kDa protein known to function as a deubiquitinase (DUB); removing ubiquitin modifiers, which alter the function of other proteins via targeted degradation, subcellular localization, or activity. By removing ubiquitin, BAP-1 helps regulate the function of target proteins involved in diverse cellular processes.
BAP-1 was expressed in most normal cells, but deletion of expression has been found in mesothelioma.
Germline mutations in the BAP-1 gene have been associated with BAP-1 tumor predisposition syndrome, a condition linked to early onset and/or increased risk of multiple types of cancers including uveal melanoma, malignant mesothelioma, cutaneous melanoma, and renal cell carcinoma."
BAP-1 was expressed in most normal cells, but deletion of expression has been found in mesothelioma.
Germline mutations in the BAP-1 gene have been associated with BAP-1 tumor predisposition syndrome, a condition linked to early onset and/or increased risk of multiple types of cancers including uveal melanoma, malignant mesothelioma, cutaneous melanoma, and renal cell carcinoma."
Specifications
- Catalog No.
- BX50278
- Clone No.
- BP6255
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Mesothelioma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide. This information is proprietary to Biolynx.
Reference
1. Citterio E. Front Genet. 2015; 6:282.
2. Murali R, Wiesner T, Scolyer RA. Pathology. 2013 Feb; 45(2):116-26.
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