Tonsil
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Bcl-6 Recombinant Rabbit Monoclonal Antibody
"Bcl-6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.The mitogen-activated protein kinases, Erk1 and Erk2, but not JNK, phosphorylate BCL6 at multiple sites. Phosphorylation of BCL6 at Ser333 and Ser343 results in degradation of BCL6 by the ubiquitin/proteasome pathway in B cells. In addition, BCL6 is acetylated and its transcriptional repressor function is inhibited by the transcriptional co-activator p300.
Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease.
Bcl-6 combined with CD10 can be used to distinguish follicular lymphoma from other lymphomas. Bcl-6 combined with CD10 and MUM1 can be used for the classification of diffuse large B-cell lymphoma."
Antibodies to this protein stain the germinal center cells in lymphoid follicles, follicular cells and interfollicular cells in Follicular Lymphoma, Diffuse Large B-Cell Lymphomas, Burkitt’s Lymphoma, and the majority of the Reed-Sternberg cells in Nodular Lymphocyte-Predominant Hodgkin’s Disease.
Bcl-6 combined with CD10 can be used to distinguish follicular lymphoma from other lymphomas. Bcl-6 combined with CD10 and MUM1 can be used for the classification of diffuse large B-cell lymphoma."
Specifications
- Catalog No.
- BX50284
- Clone No.
- BP6261
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Tonsil
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Recombinant protein fragment of Bcl-6 was used as an immunogen. This information is proprietary to Biolynx.
Reference
1. Shvarts, A. et al. (2002) Genes Dev 16, 681-6.
2. Bereshchenko, O.R. et al. (2002) Nat Genet 32, 606-13.
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