Kidney
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BRG1 Recombinant Rabbit Monoclonal Antibody
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex.
Specifications
- Catalog No.
- BX50224
- Clone No.
- BP6201
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Kidney
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Full length protein corresponding to Human BRG1.
Reference
1. Euskirchen G., Auerbach R.K., Snyder M.J. Biol. Chem. 287:30897-30905(2012).
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