CD21 also known as complement C3d receptor, Epstein-Barr virus receptor, and complement receptor type 2 (CR2), is a protein that in humans is encoded by the CR2 gene. This protein is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation.It is expressed by follicular dendritic cells (FDC) and mature B cells, as well as by several types of epithelial cells. CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue, and also useful in identifying abnormal
Specifications
Catalog No.
BX50010
Clone No.
BP6015
Application
IHC-P
Subcellular location
Membrane
Control
Tonsil
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to CD21 residues within aa933‐C terminal of CD21 was used as an immunogen.
Reference
1.Barel M, et al. Mol Immunol. 1995 Apr;32(6):389-97.
2.Tanner J, et al. J Virol. 1988 Dec;62(12):4452-64.