CD23 antigen is a transmembrane glycoprotein by various hematopoietic cell types and functions as a low-affinity receptor for IgE. CD23 is involved in regulating IgE production and has other potential biologic functions, including promoting the survival of germinal center B lymphocytes.
CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative.
CD23 has been shown to be useful for the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.
Synthetic peptide corresponding to CD34 residues within aa285-385 of CD34 was used as an immunogen.
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