Cytokeratin 8 (CK8) is a member of the type II intermediate filament (IF) gene family, the majority of the cellular CK8 is assembled with its partner, CK18, into highly insoluble 10 nm filaments that extend from the nucleus to the internal leaflet of the plasma membrane.CK8 is always expressed by simple epithelial cells and by some carcinoma cells. In non-cancerous tissue, CK8 commonly expressed in normal glandular epithelia, transitional cell epithelium, and hepatocyte. In cancerous tissue, CK8 high expressed in adenocarcinoma, such as human breast or colorectal carcinoma.
Synthetic peptide corresponding to CK-8 residues within aa383‐C terminal of CK-8 was used as an immunogen.
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