Granzyme B is serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Granzyme B is synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degradation. Recent studies have demonstrated that the expression of granzyme B by immunohistochemistry in several entities of extranodal peripheral T cell lymphoma (PTCL) and NK cell lymphomas, including nasal and nasal-type NK/T cell lymphomas, hepatosplenic and non-hepatosplenic PTCL, enteropathy-type (ETCL) and non-ETCL intestinal PTCL, subcutaneous panniculitis-like PTCL (SPTCL), cutaneous CD8+ epidermotropic lymphomas as well as in nodal and cutaneous CD30+ anaplastic large cell lymphomas (ALCL). The expression of cytotoxic proteins, such as granzyme B may be important for the identification and classification of extranodal T- and NK-cell lymphomas since many of these tumors do not have specific morphology and phenotype.
Specifications
Catalog No.
BX50024
Clone No.
BP6029
Application
IHC-P
Subcellular location
Cytoplasm
Control
Spleen
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to Granzyme B residues within aa100-200 of Granzyme B was used as an immunogen.