N-Cadherin is a member of the cadherin family of calcium dependent cell adhesion molecules. Cadherins play an important role in cell-cell adhesion, and are implicated in segregation and aggregation of tissues during development. N-Cadherin is reported to be expressed in various cell types including neural, myocardial and mesenchymall cells.
N-cadherin is useful to classification of malignant noncarcinomatous neoplasms including mesotheliomas, chordomas, synovial sarcomas, malignant melanomas, epithelioid sarcomas, epithelioid angiosarcomas, clear cell sarcomas as well as serous and endometrioid tumors of the ovary.
Specifications
Catalog No.
BX50090
Clone No.
BP6095
Application
IHC-P
Subcellular location
Membrane & Cytoplasm
Control
Mesothelioma
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within CTerm of N-Cadherin was used as an immunogen.
Reference
1. Rai H , Ahmed J. Internet Journal of Oncology, 2014, 10(1).
2. Thirkettle I , Harvey P , Hasleton P S , et al. Histopathology, 2010, 36(6):522-528