Lung adenocarcinoma
Lung adenocarcinoma
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Napsin A Recombinant Rabbit Monoclonal Antibody
Napsin A is a pepsin-like aspartic proteinase contains 420 amino acids. It is predominantly expressed in the lung and kidney. In the lung, Napsin A is expressed in alveolar type II pneumocytes, regulated by TTF-1, and is involved in the generation of the surfactant protein B. Intra-alveolar macrophages contain Napsin A as a result of phagocytosis. In the kidney, Napsin A is expressed in the proximal tubules, where it is involved in lysosomal protein catabolism.Napsin A is important in the differential diagnosis of lung adenocarcinoma vs. squamous cell carcinoma, used in a panel with TTF-1, CK5 and p63. For tumours presenting as adenocarcinoma of unknown origin, the identification of a lung origin may be aided by NapA together with TTF1, and renal origin by NapA together with PAX8.
Specifications
- Catalog No.
- BX50078
- Clone No.
- BP6083
- Application
- IHC-P
- Subcellular location
- Cytoplasm
- Control
- Lung adenocarcinoma
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to residues within aa50-150 of Napsin A was used as an immunogen.
Reference
1.Agackiran Y, Ozcan A, Akyurek N, Memis L. Appl Immunohistochem Mol Morphol. 2012 Jul;20(4):350-5.
2.Chernock RD, El-Mofty SK, Becker N, Lewis JS Jr. Am J Surg Pathol. 2013 May 15.
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