p120 Recombinant Rabbit Monoclonal Antibody

Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins.

p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin.

Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.

Specifications

Catalog No.
BX50070
Clone No.
BP6075
Application
IHC-P
Subcellular location
Cytoplasm/Membrane
Control
Colon
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to p120 residues within aa900-1000 of p120 was used as an immunogen.

Reference

1.Talvinen K, et al. Altered expression of p120 catenin predicts poor outcome in invasive breast cancer. J Cancer Res Clin Oncol. 2010 Sep; 136(9):1377-87.
2.Chivukula M, et al. Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile. Am J Surg Pathol. 2008 Nov; 32(11):1721-6.

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