Progesterone Receptor Recombinant Rabbit Monoclonal Antibody

Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets.
The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Specifications

Catalog No.
BX50076
Clone No.
BP6081
Application
IHC-P
Subcellular location
Nucleus
Control
Breast cancer
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant protein corresponding to residues within aa400-600 of progesterone receptor was used as an immunogen.

Reference

1.Bardou V-J, Arpino G, Elledge RM, et al. J Clin Oncol 2003;21:1973-1979.
2.Elledge RM, Green S, Pugh R et al.  Int J Cancer 2000;89:111-117. 

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