ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium.
Specifications
Catalog No.
BX50238
Clone No.
BP6215
Application
IHC-P
Subcellular location
Cytoplasm
Control
NSCLC
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant protein fragment of human ROS1.
Reference
1. Matsushime, H. et al. (1986) Mol Cell Biol 6, 3000-4.
2. Charest, A. et al. (2003) Genes Chromosomes Cancer 37, 58-71.