Type I Cytokeratins Recombinant Rabbit Monoclonal Antibody

The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation.This antibody can detect high molecular weight CK10, CK14, CK15 and CK16 and low molecular weight CK19. It usually used in a cytokeratin cocktail with type II cytokeratin antibody.

Specifications

Catalog No.
BX50046
Clone No.
BP6051
Application
IHC-P
Subcellular location
Cytoplasm
Control
Cervix cancer
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to Type I Cytokeratins residues within aa100-200 of Type I Cytokeratins was used as an immunogen.

Reference

1.Spagnolo DV, et al. Am J Clin Pathol. 1985 Dec;84(6):697-704.
2.Eichner R, et al. J Cell Biol. 1984 Apr;98(4):1388-96.

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