Breast cancer
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Beta-Catenin Recombinant Rabbit Monoclonal Antibody
Beta-Catenin is a key regulatory protein in Wnt signaling, a pathway that transmits signals from the cytoplasm to the nucleus, turning on the expression of specific genes in the nucleus.Under normal conditions, Beta-Catenin exists mainly in the cell membrane of normal cells, and gene mutations lead to accumulation in the nucleus. At present, Beta-Catenin gene mutation has been found in various tumors, such as colon cancer, lung cancer, prostate cancer, esophageal cancer, breast cancer, ovarian cancer, endometrial cancer, familial adenomatous polyposis, solid pseudopapilloma of pancreas, etc. High levels of nucleus positivity are seen in desmoid fibromatosis, isolated fibrous tumors, synovial sarcomas and endometrial stromal sarcomas, and carcinosarcomas. It is mainly used for the diagnosis, invasion and metastasis of malignant tumor.
Specifications
- Catalog No.
- BX50181
- Clone No.
- BP6159
- Application
- IHC-P
- Subcellular location
- Membrane & Cytoplasm & Nucleus
- Control
- Breast cancer
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to Human BetaCatenin was used as an immunogen. The exact sequence is proprietary.
Reference
1. Li XG et al. Toxicol Lett 305:19-31 (2019).
2. Xu H et al. Oncol Rep 41:1180-1188 (2019).
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