CD117 Recombinant Rabbit Monoclonal Antibody

CD117 is a cell membrane protein encoded by the c-kit proto-oncogene (chromosome 4q11-12). The protein is a type III tyrosine kinase growth factor receptor for stem cell factor (SCF), also known as mast cell growth factor. CD117 is required for the development and growth of a large number of cells expressing this protein.
CD117 is expressed in mast cells, melanocytes and interstitial cells of Cajal (ICC). The cells (particularly the mast cells) show a strong membrane as well as cytoplasmic staining. CD117 moreover is expressed in various epithelia (breast, sweat glands and salivary glands, renal tubular cells, thyroid follicular cells), usually showing a weaker, cytoplasmic reaction. In tumor tissues, CD117 is expressed in most cases of Gastrointestinal stromal tumor (GIST), mast cell neoplasms, malignant melanoma (however, the expression of CD117 is lost during progression and metastasising), seminoma/dysgerminoma and intratubular germ cell neoplasia, endometrial carcinoma, follicular and papillary thyroid carcinoma, Merkel cell carcinoma, cylindroma, malignant glioma, and angiomyolipoma.CD117 may be useful for the classification of several cancers expressing c-kit, including gastrointestinal stromal tumors (GISTs), mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing's sarcoma.