INSM-1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. It plays an important role in neuroendocrine development and is required for normal differentiation of pancreatic endocrine cells. Inhibition of INSM-1 results in decreased formation of glucagon and Insulin positive cells.
Specifications
Catalog No.
BX50263
Clone No.
BP6240
Application
IHC-P
Subcellular location
Nucleus
Control
Thyroid
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide. This information is proprietary to Biolynx.
Reference
1. Chen, C., et al. 2019. Mol. Cancer Res. 17: 1597-1604.
2. Song, R., et al. 2020.Carcinogenesis 41: 326-333.