Testis
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NUT1 Recombinant Rabbit Monoclonal Antibody
Nuclear protein in testis (NUT1 or NUTM1) is a nuclear protein encoded by the NUTM1 gene on chromosome 15 and normally expressed in testicular tissues. NUT1 is an unstructured protein with few orthologs, and shuttles between the nucleus and cytoplasm. NUT cancer (formerly NUT Midline Carcinoma) occurs after a gene fusion event between NUTM1 and often a bromodomain (BRD) family gene in about 75% of cases. NUTM1 less commonly fuses with NSD3, MXD4, MGA, ZNF532, CIC, and other rare variants, which are all considered to be NUT cancers.
Specifications
- Catalog No.
- BX50244
- Clone No.
- BP6221
- Application
- IHC-P
- Subcellular location
- Nucleus
- Control
- Testis
- Recommended method
- HIER
- Volume
- 100μl/vial, 1ml/vial
- Dilution
- 1:100-1:200
- Immunogen
- Synthetic peptide corresponding to residues of NUT1 was used as an immunogen.
Reference
1. French, C.A. et al. (2003) Cancer Res 63, 304-7.
2. Haack, H. et al. (2009) Am J Surg Pathol 33, 984-91.
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