EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Lung Carcinoma Tissue
Synthetic peptide corresponding to EGFR residues within aa1050-1150 of EGFR was used as an immunogen.
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