Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.Synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms.
Synaptophysin is expressed independently of other neuronal differentiation markers and may be used as a differentiation marker in tumor diagnosis.
Synthetic peptide corresponding to synaptophysin residues within aa213-313 of synaptophysin was used as an immunogen.
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