CD15 is present on greater than 90% of granulocytes including neutrophils and eosinophils, and to a lesser degree, on monocytes. CD15 is expressed in Reed-Sternberg cells of Hodgkin's disease (of the nodular sclerosis, mixed cellularity and lymphocytedepleted subtypes), and certain types of epithelial cells. It is generally agreed that the Reed-Sternberg cell variants in lymphocytepredominant Hodgkin's disease are not reactive with CD15. Positive staining for CD15 combined with a negative reaction for lymphocytic markers may provide support for Hodgkin’s disease.
Specifications
Catalog No.
BX50140
Clone No.
MMA
Application
IHC-P
Subcellular location
Membrane
Control
Spleen
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Immunized with the U-937 histiocytic cell line.
Reference
1. Pellegrini W, et al. Haematologica. 2007 May; 92(5):708-9.
2. Song JY, et al. Am J Surg Pathol. 2011 May; 35(5):767-72.