Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class Ⅰ, class Ⅱ and class Ⅲ gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex Ⅰ (MHC Ⅰ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane.
Specifications
Catalog No.
BX50257
Clone No.
BP6234
Application
IHC-P
Subcellular location
Membrane
Control
Kidney
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Recombinant protein fragment of HLA-A was used as an immunogen.
Reference
1. Wang K et al. Mol Med Rep 22:2052-2062 (2020).
2. Klein S et al. Cancer Immunol Immunother 68:973-982 (2019).