pan-TRK, Full name of NTRK: Neurotrophic Receptor Kinase. NTRK gene includes three subtypes: NTRK1, NTRK2 and NTRK3, which are located on different chromosomes.The proteins encoded by NTRK are called TRK proteins, and NTRK1, NTRK2 and NTRK3 encode TRKA, TRKB and TRKC respectively.TRK protein is a type of receptor tyrosine kinase that contains the extracellular ligand-binding region, the transmembrane region, and the intracellular kinase region.When TRK binds to the ligand, dimerization occurs, and intracellular tyrosine kinase phosphorylation, signaling downstream.
Specifications
Catalog No.
BX50233
Clone No.
BP6210
Application
IHC-P
Subcellular location
Cytoplasm
Control
Brain
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide corresponding to residues within aa350-450 of FOXP1 was used as an immunogen.
Reference
1. Brčić I, et al. Mod. Pathol. 2020 Aug 28.
2. Zhao M, et al. Histopathology 2020 Jun 26.