STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays.
Specifications
Catalog No.
BX50216
Clone No.
BP6193
Application
IHC-P
Subcellular location
Cytoplasm, Nuclears
Control
Solitary fibrous tumor
Recommended method
HIER
Volume
100μl/vial, 1ml/vial
Dilution
1:100-1:200
Immunogen
Synthetic peptide residues in human STAT6 was used as an immunogen.
Reference
1. Gao J et al. Stem Cell Res Ther 10:259 (2019).
2. Cao W et al. J Cell Mol Med 23:7029-7042 (2019).