Type II Cytokeratins Recombinant Rabbit Monoclonal Antibody
The keratins are the typical intermediate filament proteins of epithelia, showing an outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing of type I and type II molecules. In humans 54 functional keratin genes exist. They are expressed in highly specific patterns related to the epithelial type and stage of cellular differentiation.This antibody can detect high molecular weight CK1, CK2, CK3, CK4, CK5, CK6, CK7 and CK8 and . It is usually used in a cytokeratin cocktail with type I cytokeratins antibody.
Synthetic peptide corresponding to Type II Cytokeratins residues within aa300-400 of Type II Cytokeratins was used as an immunogen.
1.Spagnolo DV, et al. Am J Clin Pathol. 1985 Dec;84(6):697-704.
2.Eichner R, et al. J Cell Biol. 1984 Apr;98(4):1388-96.